What additional requirement is there for an e-script of a controlled substance prescription?

An electronic prescription for a controlled substance must include a digital signature and authentication. This requirement is in place to ensure the security and integrity of the prescription. The use of a digital signature verifies the identity of the prescriber and confirms that the prescription has not been altered since it was signed. Additionally, electronic prescriptions must follow certain protocols set forth by regulatory agencies to prevent fraud and ensure compliance with laws governing controlled substances.

Considering the other options, printing and having the patient sign the prescription would defeat the purpose of an electronic prescription, as it would introduce paper-based processes. The requirement for a barcode for tracking is not standard for e-scripts specifically and is more commonly associated with physical prescriptions or inventory management systems. Approval by a second prescriber is not a general requirement for e-prescriptions of controlled substances, making it irrelevant in this context. Thus, the inclusion of a digital signature and authentication is essential for maintaining the legitimacy and security of e-prescriptions for controlled substances.