Which of the following is NOT a permissible change to a CII prescription?

A change in the prescriber's signature is not permissible for a CII prescription because it is essential that the original intent and authorization of the prescriber are maintained throughout the prescription's lifecycle. The signature represents the prescriber’s official approval and any alteration to it not only undermines the integrity of the prescription but also raises concerns regarding the authenticity of the medication ordered.

On the other hand, changes like drug strength, dosage form, or directions can be made provided they are communicated to the pharmacist by the prescriber directly, and these changes do not alter the fundamental nature of the prescription. For example, if a patient is unable to tolerate a specific strength of medication, a change in strength may be warranted. Similarly, if a particular dosage form is not available, transitioning to a different form can sometimes be necessary. Changes to directions can also occur to better align with the patient's needs without altering the original medication prescribed.